SEMINARS
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Fall 2009
STATISTICS
COLLOQUIUM
Friday, October 9, 2009
2:30-3:00—Refreshments, Yost 327
3:00-4:00—Talk, Yost 101
Hemant Ishwaran, PhD
Department of Quantatative Health Sciences
Cleveland Clinic Foundation
A Novel Approach to Cancer Staging: Application to Esophageal Cancer
Cancer is staged into five groups, with Stage 0 generally reserved for noninvasive cancer and Stage IV for cancer that has spread to distant sites. Currently, staging of esophageal cancer is based solely on anatomic extent of disease using an orderly, progressive grouping of cancer classifications. However, there is growing evidence that the present stage groupings are inadequate in many regards.
In the first part of the talk I will review esophageal cancer biology. The second part will discuss a three-step random forests analysis for stage grouping using data collected from a worldwide group effort. If time permits I'll discuss some new related developments in random forest methodology.
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