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Fall 2007
STATISTICS
COLLOQUIUM
Wednesday, November 7, 2007
3:30-4:00—Refreshments--Yost 327
4:00-5:00—Talk--Yost 101
John Barnard, PhD
Department of Quantitative Health Sciences
Cleveland Clinic
Genome-Wide Association Studies: A Look at Their Past, Present, and Future
Numerous genome-wide association studies (GWAS), where a larger number
of genetic markers (e.g., 500,000 SNPs) are screened for association with phenotypes of interest, have been conducted and published in the
last two years. Examples include studies of complex diseases such as age-related macular degeneration, atrial fibrillation, inflammatory
bowel disease, coronary artery disease, diabetes mellitus, amyotrophic lateral sclerosis, multiple sclerosis, restless legs syndrome, and
various cancers. How to best design and analyze GWAS is unclear and is the focus of intense current research. We will review the design and
analysis strategies of recently published GWAS, discuss some of the proposed analysis approaches that attempt to bypass the limitations of
the standard per-SNP analysis strategies, and finally look at what is ahead for GWAS and their role in integrated omics for understanding
complex diseases.
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